Try The Hyve’s Custom cBioPortal Demo - Explore What’s Possible with Customization

A New Way to Experience cBioPortal

I have been working with cBioPortal for four years now, and I firmly believe that the real power of cBioPortal lies in running your own private instance — where you can add your proprietary data, customize the portal to your needs, and compare it with rich public datasets. Custom cBioPortal instances are a great way to perform collaborative data analysis of proprietary and public data within an institute or consortium. At The Hyve, we’ve spent nearly a decade scaling cBioPortal deployments within life sciences and pharma, making it easier for multiple users to collaborate on a single platform. Now, with our new demo instance, you can experience firsthand what a private deployment might look like for your organization. Check it out here.

Showcased Features: What Can You Explore in The Demo?

This demo server is designed to give you a hands-on preview of what a private cBioPortal instance could look like when tailored to your organization’s needs. It combines the core functionality available on the public portal with additional configurations and custom features that can be enabled in private deployments. Whether you're part of a research institute, hospital, or pharma company, this demo offers a glimpse into the flexible, collaborative environment that cBioPortal can provide when deployed locally.

1.  Custom-Enabled Features (Available Only in The Hyve's Demo Portal)

These features are either not enabled on the public portal or require additional configuration:

• Custom URL and Login Page

  The demo is hosted at a custom URL and features a branded login page, which can be connected to institutional authentication systems like LDAP or SSO.
   

• Single-Cell Data Visualization

  A dedicated Single Cell tab is available, allowing exploration of data from studies like MSK Spectrum and Glioblastoma CPTAC — a unique extension not found on the public portal.
   

• Orientation-Aware Structural Variant Table

  Viewable in the Prostate Cancer TCGA study, this feature is enabled via backend configuration to display detailed structural variant information. Read more about this here.

2.  Core Features from the Public cBioPortal (Also Available in the Demo)

These widely used analytical features were developed or co-developed by The Hyve and are now part of the core cBioPortal platform, available in both the public and demo portals:

• Mutational Signatures

  Analyze mutational signatures at the patient level and integrate them into your study view: Navigate to Charts → Mutational Signature to add signature data.
   

• Survival Analysis Enhancements

  Compare survival across drug types using the Survival tab, now equipped with:

  • Number-at-risk tables
  • Hazard ratio calculations
  • Landmarks for Survival Comparison 

Read more about it here.

• Genomic Evolution Tracking

  Visualize variant allele frequency changes across multiple sample groups with the Group by function. Check out our blog on this feature.
   

• Another noteworthy feature: Role-Based Access Control

  While our demo server does not currently showcase it, cBioPortal can be configured to restrict access to specific studies based on user roles. This is particularly useful in collaborative environments where access to sensitive or proprietary datasets must be limited to defined groups.

  If you're interested in how this works, feel free to explore our detailed articles on the topic:

  • Improved Findability of Datasets in cBioPortal
  • Keycloak User Management Explained

What's Next?

We are gradually rolling out more custom features developed by The Hyve, making them available for testing on this platform. If you want to see how cBioPortal can be tailored to your needs, this is the perfect way to explore the possibilities.
Whether you’re a clinical researcher, pathologist, or biotech professional, we invite you to try the demo and experience how cBioPortal can be customized to enhance your research workflows.

If you have questions or want to discuss a custom deployment, please contact us!