As part of his secondment at The Hyve, Eugenio Mazzone collaborated with the University of Turin’s Department of Veterinary Medicine to advance the Canine Cancer Genome Atlas (CCGA)—a pioneering resource designed to support comparative oncology using large-scale genomics analysis.
About the Project
The CCGA initiative integrates over 700 canine tumor samples spanning 10 histotypes, analyzed using high-throughput whole-exome sequencing and multi-omics data. Leveraging The Hyve’s expertise in data integration and visualization via cBioPortal, the team developed a robust pipeline to enable:Â
- Accurate variant calling
- Detection of copy number and structural variants
- Tumor mutational burden (TMB) profiling
- Standardized workflows for veterinary oncology data
Key Findings
- Wide variation in TMB across histotypes
- Evidence of DNA replication instability and environmental exposure links
- Molecular similarities to human cancers, reinforcing the value of cross-species studies
- Validation through comparison with previous studies and expert pathology input
Impact & Availability
This work underscores the power of comparative genomics in understanding cancer biology and opens new possibilities for translational research. The CCGA platform is designed to be clinician- and vet-friendly, serving as a valuable knowledge base for both research and clinical applications. View the poster here:Â
We invite the oncology and veterinary research communities to explore the CCGA and join us in advancing precision medicine across species.
Interested in integrating or visualizing your genomic data? Discover how The Hyve assists research teams worldwide with customized cBioPortal deployments, data loading pipelines, and training tailored to your specific needs.